aspirin decreases effects of azilsartan by pharmacodynamic antagonism. Modify Therapy/Check Closely. NSAIDs lower synthesis of vasodilating renal prostaglandins, and so impact fluid homeostasis and will diminish antihypertensive outcome.
Coadministration of riociguat (P-gp substrate) with potent P-gp inhibitors might need a decreased initial dose of 0.five mg PO TID; monitor for indications of hypotension and reduce dose if required
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Angiotensin Changing Enzyme (ACE) Inhibitors Due to the indirect outcome of aspirin over the renin-angiotensin conversion pathway, the hyponatremic and hypotensive consequences of ACE inhibitors might be diminished by concomitant administration of aspirin.
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